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Introduction: Vulvo-vaginal atrophy affects the daily lives of most post-menopausal women. We know that ospemifene intake can induce vaginal epithelial improvements within a few weeks; however, direct evidence of the effects of ospemifene on the human vulva and on connective tissue of both the vagina and vulva are lacking. Methods: 20 women who attended our gynecologic clinic for planned surgery were recruited for the study. Vaginal and vulvar biopsies were taken during surgery. Main outcome measure: We analyzed histological features of the epithelial and stromal layer of the vaginal and vulvar vestibule mucosa.
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Ideal animal models are needed to reflect the changes in the biochemical and biomechanical properties of the vagina that occur in pelvic organ prolapse POP. In this study, we aimed to demonstrate the short and long-term effect of menopause on the biochemical and biomechanical properties of rat anterior vaginas. Here, Sprague-Dawley rats were bilaterally ovariectomized to induce menopause. Uniaxial biomechanical testing was conducted in the control group and ovariectomized rats 16 weeks after ovariectomy. Compared with the control group, the ovariectomy group showed a significant increase in the expression of collagen I 2 weeks after ovariectomy, while collagen III showed a declining trend.
People with genital psoriasis typically experience psoriasis in other areas of their body. Treating psoriasis in an area with such sensitive skin requires specialized care. While genital psoriasis may not be often talked about, it is both common and manageable. Inverse psoriasis and plaque psoriasis are two common types of psoriasis that you may experience in the genital area.